Fernand Labrie

Publications

Page 3 of 4, showing 50 records out of 165 total, starting on record 101, ending on 150

Publication Category Year
160. Labrie, F. (1991) Intracrinology. Mol. Cell. Endocrinol., 78: C113-C118. DHEA 1991
168. Labrie, C., Simard, J., Zhao, H.F., Bélanger, A., Pelletier, G., Labrie, F. (1990) Stimulation of androgen-dependent gene expression by the adrenal precursors dehydroepiandrosterone and androstenedione in the rat ventral prostate. In: Bradlow, H., Castagnetta, L., d'Aquino, S. et Labrie, F. eds. Steroid Formation, Degradation and Action in Peripheral Tissues, Normal and Neoplastic Tissues. Ann. New York Acad. Sci. pp 395-398. DHEA 1990
167. Labrie, C., Simard, J., Poulin, M., Bélanger, A., Pelletier, G., Labrie, F. (1990) Influence of the duration of androgen deprivation on the sensitivity of the rat ventral prostate to dehydroepiandrosterone and androstenedione. In: Bradlow, H., Castagnetta, L., d'Aquino, S. et Labrie, F. eds. Steroid Formation, Degradation and Action in Peripheral Tissues, Normal and Neoplastic Tissues. Ann. New York Acad. Sci. pp 392-394. DHEA 1990
96. Labrie, C., Flamand, M., Bélanger, A., Labrie, F. (1996) High bioavailability of DHEA administered percutaneously in the rat. J. Endocrinol., 150: S107-S118. DHEA 1996
4703. Forsblad d'Elia, H., Carlsten, H., Labrie, F., Konttinen, Y., Ohlsson, C. (2009) Low serum levels of sex-steroids are associated with disease characteristics in primary Sjögren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations, J Clin Endocrinol Metab, 94: 2044-51. DHEA 2009
572. Faucher, F., Pereira de Jésus-Trans, K., Cantin, L., Luu-The, V., Labrie, F., Breton, R. (2006) Crystal structures of mouse 17beta-hydroxysteroid dehydrogenase (Apoenzyme and enzyme-NADP(H) binary complex): Identification of molecular determinants responsible for the unique 17beta-reductive activity of this enzyme. J.Mol. Biol., 364: 747-763. DHEA 2006
4685. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) The crystal structure of human delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry, 47: 8261-8270. DHEA 2008
4697. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Biochemistry, 47: 13537-13546. DHEA 2008
4696. Eriksson, A.L., Lorentzon, M., Vandenput, L., Labrie, F., Lindersson, M., Syvänen, A.C., Orwoll, E.S., Cummings, S.R., Zmuda, J.M., Ljunggren, O., Karlsson, M.K., Mellström, D., Ohlsson, C. (2009) Genetic Variations in Sex Steroid-Related Genes as Predictors of Serum Estrogen Levels in Men. J. Clin Endocrinol, Metab, 94: 1033-1041. DHEA 2009
571. Eriksson, A.L., Lorentzon, M., Mellstrom, D., Vandenput, L., Swanson, C., andersson, N., Hammond, G.L., Jakobsson, J., Rane, A., Orwoll, E.S., Ljunggren, O., Johnell, O., Labrie, F., Windahl, S.H., Ohlsson, C. (2006) SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. J Clin Endocrinol Metab, 91: 5029-37. DHEA 2006
387. Dimitrakakis, C., Zhou, J., Wang, J., Belanger, A., Labrie, F., Cheng, C., Powell, D., Bondy, C. (2003) A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause, 10: 292-298. DHEA 2003
363. Diamond, P., Cusan, L., Gomez, J.L., Bélanger, A., Labrie, F. (1996) Metabolic effects of 12-month percutaneous DHEA replacement therapy in postmenopausal women. J. Endocrinol., 150 Suppl.: S43-S50. DHEA 1996
632. Dalla Valle, L., Couet, J., Labrie, Y., Simard, J., Belvedere, P., Simontacchi, C., Labrie, F., Colombo, L. (1995) Occurrence of cytochrome 450c17 mRNA and dehydroepiandrosterone biosynthesis in the rat gastrointestinal tract. Mol. Cell. Endocrinol., 111: 83-92. DHEA 1995
637. Cusan, L., Dupont, A., Gomez, J.L., Tremblay, R.R., Labrie, F. (1994) Comparison of Flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil. Steril., 61: 281-287. DHEA 1994
426. Couillard, S., Labrie, C., Bélanger, A., Candas, B., Pouliot, F., Labrie, F. (1998) Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts. J. Natl. Cancer Inst., 90: 772-778. DHEA 1998
570. Compère, V., Ouellet, J., Luu-The, V., Dureuil, B., Tonon, M.C., Vaudry, H., Labrie, F., Pelletier, G. (2006) Role of androgens and glucocorticoids in the regulation of diazepam-binding inhibitor mRNA levels in male mouse hypothalamus. Brain Res. 1119: 50-7. DHEA 2006
591. Ciobanu, L.C., Luu-The, V., Martel, C., Labrie, F., Poirier, D. (2003) Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Res., 63: 6442-6446. DHEA 2003
569. Chouinard, S., Tessier, M., Vernouillet, G., Gauthier, S., Labrie, F., Barbier, O., Bélanger, A. (2006) Inactivation of the pure antiestrogen Fulvestrant and other synthetic estrogen molecules by UGT1A enzymes expressed in the breast tissue. Mol Pharmacol, 69: 908-20. DHEA 2006
4693. Calvo, E., Luu-The, V., Morissette, J., Martel, C., Labrie, C., Bernard, B., Bernerd, F., Deloche, C., Chaussade, V., Leclaire, J., Labrie, F., (2008) Pangenomic Changes Induced by DHEA in the Skin of Postmenopausal Women. J Steroid Biochem Mol Biol, 112: 186-193 DHEA 2008
56. Boivin, R.P., Poirier, D., Labrie, F. (1999) 17alpha-alkan (or alkyn) amide derivatives of estradiol as inhibitors of steroid-sulfatase activity. Steroids, 64: 825-833. DHEA 1999
605. Boivin, R.P., Luu-The, V., Lachance, R., Labrie, F., Poirier, D. (2000) Structure-activity relationships of 17alpha-derivatives of estradiol as inhibitors of steroid sulfatase. J. Med. Chem., 43: 4465-4478. DHEA 2000
358. Berger, L., El-Alfy, M., Martel, C., Labrie, F. (2005) Effects of DHEA, Premarin and Acolbifene on histomorphology and sex steroid receptors of the rat vagina. J Steroid Biochem Mol Biol, 96: 201-15. DHEA 2005
373. Berger, L., El-Alfy, M., Labrie, F. (2008) Effects of intravaginal dehydroepiandrosterone on vaginal histomorphology, sex steroid receptor expression and cell proliferation in the rat. J Steroid Biochem Mol Biol, 109: 67-80. DHEA 2008
568. Bellemare, V., Labrie, F., Luu-The, V. (2006) Isolation and characterization of a cDNA encoding mouse 3beta-hydroxysteroid dehydrogenase an androgen-inactivating enzyme selectively expressed in female tissues. J Steroid Biochem Mol Biol, 98: 18-24. DHEA 2006
4718. Basson, R., Brotto, L.A., Petkau, A.J., Labrie, F. (2010) Role of androgens in women's sexual dysfunction. Menopause. 17: 962-971. DHEA 2010
178. Bélanger, B., Bélanger, A., Labrie, F., Dupont, A., Cusan, L., Monfette, G. (1989) Comparison of residual C-19 steroids in plasma and prostatic tissue of human, rat and guinea pig after castration: unique importance of extratesticular androgens in men. J. Steroid Biochem., 32: 695-698. DHEA 1989
121. Bélanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.L., Labrie, F. (1994) Changes in serum concentration of conjugated and unconjugated steroids in 40- to 80-year old men. J. Clin. Endocrinol. Metab., 79: 1086-1090. DHEA 1994
581. Azzi, L., El-Alfy, M., Martel, C., Labrie, F. (2005) Gender differences in mouse skin morphology and specific effects of sex steroids and dehydroepiandrosterone. J Invest Dermatol, 124: 22-7. DHEA 2005
4722. Vanderschueren, D., Pye, S.R., Venken, K., Borghs, H., Gaytant, J., Huhtaniemi, I.T., Adams, J.E., Ward, K.A., Bartfai, G., Casanueva, F.F., Finn, J.D., Forti, G., Giwercman, A, Han, T.S., Kula, K., Labrie, F., Lean, M.E., Pendleton, N., Punab, M., Silman, A.J., Wu, F.C, O’Neill, T.W, Boonen, S., The EMAS Study Group (2010) Gonadal sex steroid status and bone health in middle-aged and elderly European men. Osteoporosis Int. 21:1331-1339. DHEA 2010
4744. Jedel, E., Labrie, F., Odén, A., Holm G., Nilsson, L., Janson, P.O., Lind, A.K., Ohlsson, C., Stener-Victorin, E. (2011) Impact of electro-acupuncture and physical exercise on hyperandrogenism and oligo/amenorrhoea in women with polycystic ovary syndrome: A randomized controlled trial. Am J Physiol Endocrinol & Metab. 300:E37-E45. DHEA 2011
4739. Orwoll, E.S., Nielson, C.M., Labrie, F., Barrett-Connor, E., Cauley, J.A., Cummings, S.R., Ensrud, K., Karlsson, M., Lau, E., Leung, P.C., Lunggren, Ö., Mellström, D., Patrick, A.L., Stefanick, M.L., Nakamura, K., Yoshimura, N., Zmuda, J., Vandenput, L, Ohlsson, C.,for the Osteoporotic Fractures in Men (MrOS) Research Group (2010) Evidence for Geographical and racial variation in serum sex steroid levels in older men. J Clin Endocrinol Metab. 95: E151-E160. DHEA 2010
4741. Ohlsson, C., Labrie, F., Barrett-Connor, E., Karlsson, M.K., Ljunggren, Ö., Vandenput, L., Mellström, D., Tivesten, Å. (2010) Low serum levels of dehydroepiandrosterone sulphate predict all-cause and cardiovascular mortality in elderly Swedish men. J Clin Endocrinol Metab. 95: 4406-4414. DHEA 2010
4736. Labrie, F., Martel, C., Balser, J. (2011) Wide distribution of the serum levels of DHEA and sex steroids in postmenopausal women – role of the ovary? Menopause. 18:30-43. DHEA 2011
4735. Labrie, F. (2010) Hormonal therapy of prostate cancer. In: Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff De, eds. Pathological Situations and Diseases, Progress in Brain Research. Elsevier. Chapter 14, Vol. 182 321-341. DHEA 2010
4734. Labrie, F. (2010) DHEA, important source of sex steroid in men and even more in women. In: Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff De, eds. Pathological Situations and Diseases, Progress in Brain Research. Elsevier. Chapter 4, Vol. 182 97-148. DHEA 2010
4737. Wu, FCW., Tajar, A., T., Beynon, JM., Pye, SR., Silman, AJ., Finn, JD., O’Neill, TW., Bartfai, G., Casanueva, FF., Forti, G., Giwercman, A., Han, TS., Kula, K, Lean, MEJ., Vanderschueren, D., Labrie, F., Huhtaniemi, IT.,  (2010) Identification of late-onset hypogonadism in middle-aged and elderly men. New England Journal of Medicine. 363:123-135. DHEA 2010
4711. Labrie, F., Archer, D., Bouchard, C., Fortier, M., Cusan, L., Gomez, JL., Girard, G., Baron, M., Ayotte, N., Moreau, M., Dubé, R., Côté, I, Labrie, C., Lavoie, L., Berger, L., Martel, C., Balser, J. (2010) High internal consistency and efficacy of intravaginal DHEA for vaginal atrophy. Gynecological Endocrinology, 26: 524-532. DHEA 2010
4730. Luu-The V, Labrie F. (2010) The intracrine sex steroid biosynthesis pathways. In: Martini L, Chrousos GP, Labrie F, Pacak K, Pfaff De, eds. Neuroendocrinology, Pathological Situations and Diseases,  Progress in Brain Research. Elsevier. Vol 181 (Chapter 10): 2010:177-192. DHEA 2010
4729. Huhtaniemi, I.T., Pye, S.R., Holliday, K.L., Thomson, W., O’Neill, T.W., Platt, H., Payne, D., John, S.L., Jiang, M., Bartfai, G., Boonen, S., Casanueva, F.F., Finn, J.D., Forti, G., Giwercman, A., Han, T.S., Kula, K, ;Lean, M.E.J., Pendleton, N., Punab, M., Silman, A.J., Vanderschueren, D., Wu, F.C.W. and the EMAS study group (2010) Effect of polymorphisms in selected genes involved in pituitary-testicular function on reproductive hormones and phenotype in aging men. J Clin Endocrinol Metab. 95:1898-1908. DHEA 2010
4731. Berger, L., E-Alfy, M., Martel, C., Labrie, F. (2010) Effect of long-term topical application of dehydroepiandrosterone (DHEA) and oral estrogens on morphology, cell proliferation, procollagen A1 and androgen receptor levels in rat skin. Horm Mol Biol Clin Invest 2: 267-275. DHEA 2010
4732. Lee, D., Ulubaev, A., Tajar, A., Pye, S., Pendleton, N., Purandare, N., O’Neill, T., O’Connor, D., Labrie, F., Platt, H., Payne, D., Bartfai, G., Boonen, S., Casanueva, F., Finn, J., Forti, G., Giwercman, A., Han, T., Huhtaniemi, I, Kula, K, Lean, M., Punab, M., Silman, A., Vanderschueren, D., Wu, F. (2010) Endogenous hormones, androgen receptor CAG repeat length and fluid cognition in middle-aged and older men: results from the European Male Ageing Study (EMAS). Eur J Endocrinol. 162: 1155-1164. DHEA 2010
4746. Brotto, L.A., Petkau, A.J., Labrie, F., Basson, R. (2011) Predictors of sexual desire disorders in women. Journal of Sexual Medicine. 8:742-753 DHEA 2011
4754. Labrie, F (2011) DHEA and Cancer Risk or Prevention? In: DHEA (Dehydroepiandrosterone) in Human Health and Aging, R.R.Watson ed., Taylor & Francis Group LLC, publishers, Chapter 12, pp: 153-172. DHEA 2011
4760. Ward, K.A., Pye, S.R., Adams, J.E., Boonen, S., Vanderschueren, D., Borghs, H., Gaytant, J., Gielen, E., Bartfai, G., Casanueva, F.F., Finn, J.D., Forti, G., Giwercman, A., Han, T.S., Huhtaniemi, I.T., Kula, K., Labrie, F., Lean, M.E.J., Pendleton, N., Punab, M., Silman A.J., Wu, F.C.W., O’Neill, T.W., The EMAS study group (2011) Influence of age and sex steroids on bone density and geometry in middle-aged and elderly European men. Osteoporos Int. 22:1513-1523. DHEA 2011
4756. Labrie, F. Martel, C., Balser, J. (2011) Letters to the Editor - Intracrine formation from DHEA versus ovarian secretion of testosterone. Menopause, 18: 587-591. DHEA 2011
4757. Labrie, F. (2011) Editorial: Impact of circulating DHEA on androgen formation in women. Menopause, 18: 471-473. DHEA 2011
4753. Labrie, F. (2011) Blockade of testicular and adrenal androgens in prostate cancer treatment. Nature Reviews. 8: 73-80 DHEA 2011
4749. Labrie, F. (2010) Intravaginal DHEA, by a strictly local action, exerts beneficial effects on both vaginal atrophy symptoms and sexual dysfunction. Horm Mol Biol Clin Invest. 4: 499-507 DHEA 2010
4750. Labrie, F. (2010) Editorial Comment: Kaliks RA et al. Complete androgen blockade safely allows for delay of cytotoxic chemotherapy in castration refractory prostate cancer. International Braz J Urol. 36: 306-307 DHEA 2010
4747. Labrie, F., Archer, D., Bouchard, C., Fortier, M., Cusan, L., Girard, G., Baron, M., Ayotte, N., Moreau, M., Dubé, R., Côté, I, Labrie, C., Lavoie, L., Martel, C., Balser, J. (2010) Effect of intravaginal DHEA in postmenopausal women with vaginal atrophy and pain at sexual activity (dyspareunia) as most bothersome symptom. Proceedings of the 13th World Congress on Controversies in Obstetrics, Gynecology & Infertility (COGI), November 4-7, 2010, Berlin, Germany. Code C440:234-380. DHEA 2010
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