Fernand Labrie

Publications

Page 6 of 9, showing 50 records out of 429 total, starting on record 251, ending on 300

Publication Category Year
632. Dalla Valle, L., Couet, J., Labrie, Y., Simard, J., Belvedere, P., Simontacchi, C., Labrie, F., Colombo, L. (1995) Occurrence of cytochrome 450c17 mRNA and dehydroepiandrosterone biosynthesis in the rat gastrointestinal tract. Mol. Cell. Endocrinol., 111: 83-92. Intracrinology 1995
634. Labrie, F., Bélanger, A., Simard, J., Luu-The, V., Labrie, C. (1995) DHEA and peripheral androgen and estrogen formation: intracrinology. Ann. N.Y. Acad. Sci., 774: 16-28. Intracrinology 1995
635. Luu-The, V., Dufort, I., Paquet, N., Reimnitz, G., Labrie, F. (1995) Structural characterization and expression of the human dehydroepiandrosterone sulfotransferase gene. DNA Cell Biol., 14: 511-518. Intracrinology 1995
900. Doualla-Bell, F., Bonneau, M.J., Labrie, F., Fortier, M.A. (1995) Differential effects of a steroidal antiestrogen, EM-139, on prostaglandin and cAMP production in the circular and longitudinal layers of bovine myometrium. Biol. Reprod., 52: 1358-1363. Intracrinology 1995
901. Durocher, F., Morissette, J., Labrie, Y., Labrie, F., Simard, J. (1995) Mapping of the HSD17B2 gene encoding type II 17beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q 24.1-q24.2. Genomics, 25: 724-726. Intracrinology 1995
902. Ghosh, D., Pletnev, V.Z., Zhu, D.-W., Wawrzak, Z., Duax, W.L., Pangborn, W., Labrie, F., Lin, S.-X. (1995) Structure of human estrogenic 17beta-hydroxysteroid dehydrogenase at 2.20 a resolution. Structure, 3: 503-513. Intracrinology 1995
903. Guérin, S.L., Leclerc, S., Verreault, H., Labrie, F., Luu-The, V. (1995) Overlapping cis-acting elements located in the first intron of the gene for type I 3beta-hydroxysteroid dehydrogenase modulate its transcriptional activity. Mol. Endocrinol., 9: 1583-1597. Intracrinology 1995
908. Labrie, Y., Durocher, F., Lachance, Y., Turgeon, C., Simard, J., Labrie, C., Labrie, F. (1995) The human type II 17beta-hydroxysteroid dehydrogenase gene encodes two alternatively-spliced messenger RNA species. DNA Cell Biol., 14: 849-861. Intracrinology 1995
910. Li, X., Chen, C., Singh, S.M., Labrie, F. (1995) The enzyme and inhibitors of 4-ene-3-oxosteroid 5alpha-reductase. Steroids, 60: 430-441. Intracrinology 1995
915. Luu-The, V., Zhang, Y., Poirier, D., Labrie, F. (1995) Characteristics of human types 1, 2, and 3 17beta-hydroxysteroid dehydrogenase activities: oxidation reduction and inhibition. J. Steroid Biochem. Mol. Biol., 55: 581-587. Intracrinology 1995
916. Mébarki, F., Sanchez, R., Rhéaume, E., Laflamme, N., Simard, J., Forest, M.G., Bey-Omar, F., David, M., Labrie, F., Morel, Y. (1995) Nonsalt-losing male pseudohermaphroditism due to the novel homozygous N100S mutation in the type II 3beta-hydroxysteroid dehydrogenase (HSD3B2) gene. J. Clin. Endocrinol. Metab., 80: 2127-2134. Intracrinology 1995
917. Morissette, J., Rhéaume, E., Leblanc, J.-F., Luu-The, V., Labrie, F., Simard, J. (1995) Genetic linkage mapping of HSD3B1 and HSD3B2 encoding human types I and II 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase close to D1S514 and the centromeric D1Z5 locus. Cytogenet Cell Genet, 69: 59-62. Intracrinology 1995
918. Pelletier, G., Luu-The, V., Labrie, F. (1995) Immunocytochemical localization of type I 17beta-hydroxysteroid dehydrogenase in the rat brain. Brain Res., 704: 233-239. Intracrinology 1995
919. Rhéaume, E., Sanchez, R., Mébarki, F., Gagnon, E., Carel, J.C., Chaussain, J.L., Morel, Y., Labrie, F., Simard, J. (1995) Identification and characterization of the G15D mutation found in a male patient with 3beta-hydroxysteroid dehydrogenase (3beta-HSD) deficiency: alteration of the putative NAD-binding domaine of type II 3beta-HSD. Biochemistry, 34: 2893-2900. Intracrinology 1995
920. Simard, J., Rhéaume, E., Mébarki, F., Sanchez, R., New, M.I., Morel, Y., Labrie, F. (1995) Molecular basis of human 3beta-hydroxysteroid dehydrogenase deficiency. J. Steroid Biochem. Mol. Biol., 53: 127-138. Intracrinology 1995
921. Simard, J., Sanchez, R., Durocher, F., Rhéaume, E., Turgeon, C., Labrie, Y., Luu-The, V., Mebarki, F., Morel, Y., de Launoit, Y., Labrie, F. (1995) Structure-function relationships and molecular genetics of the 3beta-hydroxysteroid dehydrogenase gene family. J. Steroid Biochem. Mol. Biol., 55: 489-505. Intracrinology 1995
924. Zhu, D.-W., Zhou, M., Mao, Y., Labrie, F., Lin, S.-X. (1995) Crystallization of human estrogenic 17beta-hydroxysteroid dehydrogenase under microgravity. J. Cryst. Growth, 156: 108-111. Intracrinology 1995
121. Bélanger, A., Candas, B., Dupont, A., Cusan, L., Diamond, P., Gomez, J.L., Labrie, F. (1994) Changes in serum concentration of conjugated and unconjugated steroids in 40- to 80-year old men. J. Clin. Endocrinol. Metab., 79: 1086-1090. Intracrinology 1994
124. Labrie, F. (1994) Intracrinology and Cancer Therapy. Science Watch, 5: 3-4. Intracrinology 1994
129. Labrie, F., Simard, J., Bélanger, A., Luu-The, V., Labrie, C. (1994) Molecular biology of the intracrine steroidogenic enzymes in the human prostate, in: Motta, M. et Serio, M., eds: Sex Hormones and Antihormones in Endocrine-Dependent Pathology: Basic and Clinical Aspects, New York, Elsevier, pp 77-92. Intracrinology 1994
130. Sugimoto, K., Simard, J., Veilleux, R., Haagensen, D.E., Labrie, F. (1994) Inverse relationships between cell proliferation and basal or androgen-stimulated apolipoprotein D secretion in LNCaP human prostate cancer cells. J. Steroid Biochem. Mol. Biol., 51: 167-174. Intracrinology 1994
365. Couët, J., Martel, C., Labrie, Y., Luo, S., Simard, J., Labrie, F. (1994) Opposite effects of prolactin and corticosterone on the expression and activity of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase in rat skin. J. Invest. Dermatol., 103: 60-64. Intracrinology 1994
366. Luu-The, V., Sugimoto, Y., Puy, L., Labrie, Y., Lopez Solache, I., Singh, M., Labrie, F. (1994) Characterization, expression and immunohistochemical localization of 5alpha-reductase in human skin. J. Invest. Dermatol., 102: 221-226. Intracrinology 1994
465. Pelletier, J.D., Labrie, F., Poirier, D. (1994) N-butyl, N-methyl, 11-3',17'β-dihydroxy-1'3'5'(10') estratrien-16'α-yl)-9-(R/S)bromo undecanamide: synthesis and 17β-HSD inhibiting activity, estrogenic activity and antiestrogenic activity. Steroids, 59: 536-547. Intracrinology 1994
466. Poirier, D., Auger, S., Mérand, Y., Simard, J., Labrie, F. (1994) Synthesis and antiestrogenic activity of diaryl thioether derivatives. J. Med. Chem., 37: 1115-1125. Intracrinology 1994
640. Labrie, Y., Couet, J., Simard, J., Labrie, F. (1994) Multihormonal regulation of dehydroepiandrosterone sulfotransferase mRNA levels in adult rat liver. Endocrinology, 134: 1693-1699. Intracrinology 1994
641. Young, J., Couzinet, B., Pholsena, M., Nahoul, K., Labrie, F., Schaison, G. (1994) Plasma 3β-hydroxy-?5-steroids in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. J. Clin. Endocrinol. Metab., 78: 299-304. Intracrinology 1994
926. Bernier, F., Leblanc, G., Labrie, F., Luu-The, V. (1994) Structure of human estrogen and aryl sulfotransferase gene: Two mRNA species issued from a single gene. J. Biol. Chem., 269: 28200-28205. Intracrinology 1994
927. Bernier, F., Lopez, I., Labrie, F., Luu-The, V. (1994) Cloning and expression of cDNA encoding human placental estrogen sulfotransferase. Mol. Cell. Endocrinol., 99: R11-R15. Intracrinology 1994
928. Breton, R., Yang, F., Jin, J.Z., Li, B., Labrie, F., Lin, S.-X. (1994) Human 17beta-hydroxysteroid dehydrogenase: overproduction using a baculovirus expression system and characterization. J. Steroid Biochem. Mol. Biol., 50: 275-282. Intracrinology 1994
930. Dionne, P., Singh, S.M., Labrie, F. (1994) 1H and 13C nuclear magnetic resonance assignments and stereochemistry of N-n-butyl-n-methyl-11-(16'α-chloro-3',17'β (and 17α)-dihydroxyestra-1',4',5'(10')-trien-7α-yl) undecanamide. Steroids, 59: 493-497. Intracrinology 1994
931. Dupont, E., Simard, J., Luu-The, V., Labrie, F., Pelletier, G. (1994) Localization of 3β-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization. Mol. Cell. Neurosci., 5: 119-123. Intracrinology 1994
934. Labrie, F., Simard, J., Luu-The, V., Pelletier, G. (1994) Molecular genetics, structure-function relationships and tissue-specific expression and tissue-specific expression and regulation of the 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene family, in: Bartke, A., ed. Function of Somatic Cells in the Testis, New York, NY, USA, Springer-Verlag, pp 126-150. Intracrinology 1994
935. Labrie, F., Simard, J., Luu-The, V., Pelletier, G., Belghmi, K., Bélanger, A. (1994) Structure, regulation and role of 3β-hydroxysteroid dehydrogenase, 17β-hydroxysteroid dehydrogenase and aromatase enzymes in formation of sex steroids in classical and peripheral intracrine tissues, in: Sheppard, M.C. et Stewart, P.M., eds: Hormones, Enzymes and Receptors, London, Baillière's clinical endocrinology and metabolism, pp 451-474. Intracrinology 1994
937. Li, X., Singh, S.M., Labrie, F. (1994) Highly efficient nucleophilic addition of alkyl Grignard reagents to 17-ketosteroids in the presence of cerium (III) chloride: synthesis of 17β-propyl-17β-hydroxy-4-androsten-3-one, an androgen receptor antagonist. Tetrahedron Lett., 35: 1157-1160. Intracrinology 1994
939. Martel, C., Gagné, D., Couet, J., Labrie, Y., Simard, J., Labrie, F. (1994) Rapid modulation of ovarian 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase gene expression by prolactin and human chorionic gonadotropin in the hypophysectomized rat. Mol. Cell. Endocrinol., 99: 63-71. Intracrinology 1994
940. Pelletier, G., Luu-The, V., Labrie, F. (1994) Immunocytochemical localization of 5α-reductase in rat brain. Mol. Cell. Neurosci., 5: 394-399. Intracrinology 1994
943. Rhéaume, E., Sanchez, R., Simard, J., Chang, Y.T., Wang, J., Pang, S., Labrie, F. (1994) Molecular basis of congenital adrenal hyperplasia in two sibs with classical nonsalt-losing 3β-hydroxysteroid dehydrogenase deficiency. J. Clin. Endocrinol. Metab., 79: 1012-1018. Intracrinology 1994
944. Sanchez, R., de Launoit, Y., Durocher, F., Bélanger, A., Labrie, F., Simard, J. (1994) Formation and degradation of dihydrotestosterone by recombinant members of the rat 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) family. Mol. Cell. Endocrinol., 103: 29-38. Intracrinology 1994
945. Sanchez, R., Mebarki, F., Rheaume, E., Laflamme, N., Forest, M.G., Bey-Omard, F., David, M., Morel, Y., Labrie, F., Simard, J. (1994) Functional characterization of the novel L108W and P186L mutations detected in the type II 3β-hydroxysteroid dehydrogenase gene of a male pseudohermaphrodite with congenital adrenal hyperplasia. Hum. Mol. Genet., 3: 1639-1645. Intracrinology 1994
946. Sanchez, R., Rhéaume, E., Laflamme, N., Rosenfield, R.L., Labrie, F., Simard, J. (1994) Detection and functional characterization of the novel missense mutation Y254D in type II 3β-hydroxysteroid dehydrogenase (3β-HSD) gene of a female patient with nonsalt-losing 3β-HSD deficiency. J. Clin. Endocrinol. Metab., 78: 561-567. Intracrinology 1994
947. Simard, J., Rhéaume, E., Leblanc, J.F., Wallis, S.C., Joplin, G.F., Gilbey, S., Allanson, J., Mettler, G., Bettendorf, M., Heinrich, U., Labrie, F. (1994) Congenital adrenal hyperplasia caused by a novel homozygous frameshift mutation 273DAA in type II 3β-hydroxysteroid dehydrogenase gene (HSD3β2) in three male patients of Afghan/Pakistani origin. Hum. Mol. Genet., 3: 327-330. Intracrinology 1994
949. Verreault, H., Dufort, I., Simard, J., Labrie, F., Luu-The, V. (1994) Dinucleotide repeat polymorphisms in the HSD3?2 gene. Hum. Mol. Genet., 3: 384. Intracrinology 1994
951. Zerah, M., Rhéaume, E., Mani, P., Schram, P., Simard, J., Labrie, F., New, M.I. (1994) No evidence of mutations in the genes for type I and type II 3β-hydroxysteroid dehydrogenase (3β-HSD) in nonclassical 3β-HSD deficiency. J. Clin. Endocrinol. Metab., 79: 1811-1817. Intracrinology 1994
952. Zhu, D.-W., Lee, X., Labrie, F., Lin, S.-X. (1994) Crystal growth of human estrogenic 17β-hydroxysteroid dehydrogenase. Acta Crystallogr., D50: 550-555. Intracrinology 1994
135. Labrie, F. (1993) Intracrinology: its impact on prostate cancer. Curr. Opin. Urol., 3: 381-387. Intracrinology 1993
136. Labrie, F. (1993) Mechanism of action and pure antiandrogenic properties of Flutamide. Cancer, 72: 3816-3827. Intracrinology 1993
137. Labrie, F. (1993) Non-steroidal antiandrogens, in: Droz, J.P., Cvitkovic, E., Armand, J.P. et Khoury, S., eds: Handook of Chemotherapy in Clinical Oncology, London, Scientific Communication International Ltd., pp 389-391. Intracrinology 1993
139. Labrie, F., Bélanger, A., Dupont, A., Luu-The, V., Simard, J., Labrie, C. (1993) Science behind total androgen blockade: from gene to combination therapy. Clin. Invest. Med., 16: 475-492. Intracrinology 1993
143. Labrie, F., Dupont, A., Simard, J., Luu-The, V., Bélanger, A. (1993) Intracrinology: the basis for the rational design of endocrine therapy at all stages of prostate cancer. Eur. Urol., 24 Suppl. 2: 94-105. Intracrinology 1993
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