Fernand Labrie

Publications

Page 1 of 25, showing 50 records out of 1210 total, starting on record 1, ending on 50

Publication Category Year
1210. Bydal, P., Luu-The, V., Labrie, F., Poirier, D. (2008) Steroidal lactones as inhibitors of 17beta-hydroxysteroid dehydrogenase type 5: Chemical synthesis, enzyme inhibitory activity, and assessment of estrogenic and androgenic activities. Eur J Med Chem. in press. All publications 2008
1209. Labrie, F. (2008) Preface. Best Pract Res Clin Endocrinol Metab, 22: pp. vii-ix. All publications 2008
1208. Luu-The, V., Bélanger, A., Labrie, F. (2008) Androgen biosynthetic pathways in the human prostate. Best Pract Res Clin Endocrinol Metab, 22: 207-221. All publications 2008
1207. Ma, C., Yoshioka, M., Boivin, A., Belleau, P., Gan, L., Takase, Y., Labrie, F., St-Amand, J. (2008) Prostate specific genes and their regulation by dihydrotestosterone. Prostate, 68: 241-254. All publications 2008
1206. Labrie, F., Cusan, L., Gomez, J.L., Côté, I., Bérubé, R., Bélanger, P., Martel, C., Labrie, C. (2008) Effect of One-Week Treatment with Vaginal Estrogen Preparations on Serum Estrogen Levels in Postmenopausal Women. Menopause, in press. All publications 2008
1205. Donet, E., Bayo, P., Calvo, E., Labrie, F., Pérez, P. (2008) Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation. J Steroid Biochem Mol Biol, 108: 8-16. All publications 2008
1204. Berger, L., El-Alfy, M., Labrie, F. (2008) Effects of intravaginal dehydroepiandrosterone on vaginal histomorphology, sex steroid receptor expression and cell proliferation in the rat. J Steroid Biochem Mol Biol, 109: 67-80. All publications 2008
1203. Labrie, F. (2008) Combination of Breast Cancer Prevention with Tissue-Targeted Hormone Replacement Therapy, In: Breast Cancer - Prognosis, Treatment, and Prevention, Second Edition, Pasqualini, J.R., ed., pp. 201-252. All publications 2008
1202. Pelletier, G., Labrie, C., Martel, C., Labrie, F. (2008) Chronic administration of dehydroepiandrosterone (DHEA) to female monkey and rat has no effect on mammary gland histology. J Steroid Biochem Mol Biol, 108: 102-108. All publications 2008
1201. Labrie, F., Cusan, L., Gomez, J.L., Martel, C., Bérubé, R., Bélanger, P., Chaussade, V., Deloche, C., Leclaire, J. (2008) Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol, 110: 1-9. All publications 2008
1200. Labrie, F., Koutsilieris, M. (2008) The 12th International Congress on Hormonal Steroids and Hormones & Cancer. J Steroid Biochem Mol Biol, 108: 179. All publications 2008
1199. Labrie, F., Cusan, L., Gomez, J.L., Côté, I., Bérubé, R., Bélanger, P., Martel, C., Labrie, C. (2008) Effect of Intravaginal DHEA on Serum DHEA and Eleven of its Metabolites in Postmenopausal Women. J Steroid Biochem Mol Biol, 111: 178-94 All publications 2008
1198. Ivanga, M., Labrie, Y., Calvo, E., Belleau, P., Martel, C., Pelletier, G., Morissette, J., Labrie, F., Durocher, F. (2008) Fine temporal analysis of DHT transcriptional modulation of the ATM/Gadd45g signaling pathways in the mouse uterus. Mol Reprod Dev, in press. All publications 2008
1197. Spitz, IM., Chertin, B., Fridmans, A., Farkas, A., Bélanger, A., Hartman, H., Labrie, F. (2008). Partial androgen suppression consequent to increased secretion of adrenal androgens in a patient with prostate cancer treated with long-acting GnRH agonists. Prostate Cancer Prostatic Dis, in press. All publications 2008
1196. Zhang, Y., Calvo, E., Martel, C., Luu-The, V., Labrie, F., Tchernof, A. (2008) Response of the adipose tissue transcriptome to dihydrotestosterone in mice. Physiol Genomics 35: 254-261 All publications 2008
1195. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) The crystal structure of human delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry, 47: 8261-8270. All publications 2008
1194. Mellström, D., Vandenput, L., Mallmin, H., Holmberg, AH., Lorentzon, M., Odén, A., Johansson, H., Orwoll, ES., Labrie, F., Karlsson, MK., Ljunggren, Ö., Ohlsson C. (2008) Older men with low serum estradiol and high serum SHBG have an increased risk of fractures. J Bone Miner Res, 23: 1552-1560. All publications 2008
1193. Ma, C., Yoshioka, M., Boivin, A., Belleau, P., Gan, L., Takase, Y., Labrie, F., St-Amand, J. (2008) Erratum: Prostate specific genes and their regulation by dihydrotestosterone. Prostate, 68: 1372. All publications 2008
1192. Labrie, F., Cusan, L., Gomez, J.L., Côté, I., Bérubé, R., Bélanger, P., Martel, C., Labrie, C. (2008) Corrigendum to: Effect of Intravaginal DHEA on Serum DHEA and Eleven of its Metabolites in Postmenopausal Women. J Steroid Biochem Mol Biol, 112: 169 All publications 2008
1191. Han, B., Li, S., Song, D., Poisson-Paré, D., Liu, G., Luu-The, V., Ouellet, J., Li, S., Labrie, F., Pelletier, G. (2008) Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters. J Steroid Biochem Mol Biol, 112: 194-200 All publications 2008
1190. Labrie, F., Cusan, L., Gomez, J.L., Martel, C., Bérubé, R., Bélanger, P., Bélanger, A., Vandenput, L., Mellström, D., Ohlsson, C. (2008) Comparable Amounts of Sex Steroids are Made Outside the Gonads in Men and Women: Strong Lesson for Hormone Therapy of Prostate and Breast Cancer. In press All publications 2008
1189. Calvo, E., Luu-The, V., Morissette, J., Martel, C., Labrie, C., Bernard, B., Bernerd, F., Deloche, C., Chaussade, V., Leclaire, J., Labrie, F., (2008) Pangenomic Changes Induced by DHEA in the Skin of Postmenopausal Women. J Steroid Biochem Mol Biol, 112: 186-193 All publications 2008
1188. Labrie, F. (2008) Comment to: Prostate specific antigen (PSA)-based screening. Int J Urol, 15: 757-762. All publications 2008
1187. Eriksson, A.L., Lorentzon, M., Vandenput, L., Labrie, F., Lindersson, M., Syvänen, A.C., Orwoll, E.S., Cummings, S.R., Zmuda, J.M., Ljunggren, O., Karlsson, M.K., Mellström, D., Ohlsson, C. (2008) Genetic Variations in Sex Steroid-Related Genes as Predictors of Serum Estrogen Levels in Men. J. Clin Endocrinol, Metab, in press. All publications 2008
1186. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) Crystal structures of human 4-3-ketosteroid 5-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Biochemistry, 47: 13537-13546. All publications 2008
1185. Akaza, H., Labrie, F., Namiki, M. (2007) [A way of thinking of a MAB therapy for local/locally advanced prostate cancer: the theory and recent evaluation]. Gan To Kagaku Ryoho. Jpn J Cancer Chemotherapy, 34: 657-669. All publications 2007
1184. Cantin, L., Faucher, F., Couture, J.F., de Jésus, K.P., Legrand, P., Ciobanu, L., Fréchette, Y., Labrecque, R., Singh, S.M., Labrie, F., Breton, R. (2007) Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally-designed steroidal ligand bearing a bulky chain directed toward helix 12. J Biol Chem, 282: 30910-9. All publications 2007
1183. Labrie, F. (2007) Multiple intracrine hormonal targets in the prostate: oportunities and challenges. BJU Int, 100: 48-51. All publications 2007
1182. Levesque, M.H., El-Alfy, M., Berger, L., Labrie, F., Labrie, C. (2007) Evaluation of AIbZIP and Cdc47 as Markers for Human Prostatic Diseases. Urology, 69: 196-201. All publications 2007
1181. Roy, J., Breton, R., Martel, C., Labrie, F., Poirier, D. (2007) Chemical synthesis and biological activities of 16?-derivatives of 5?-androstane-3?, 17?-diol as antiandrogens. Bioorg Med Chem, 15: 3003-3018. All publications 2007
1180. Suzuki, K., Nishiyama, T., Hara, N., Yamana, K., Takahashi, K., Labrie, F. (2007) Importance of the intracrine metabolism of adrenal androgens in androgen-dependent prostate cancer. Prostate Cancer Prostatic Dis., 10: 301-6. All publications 2007
1179. Swanson, C., Mellström, D., Lorentzon, M., Vanderput, L., Jakobsson, J., Rane, A., Karlsson, M., Ljunggren, O., Smith, U., Eriksson, A.E., Bélanger, A., Labrie, F., Ohlsson, C. (2007) The uridine diphosphate glucuronosyltransferase 2B15 D85Y and 2B17deletion polymorphisms predict the glucuronidation pattern of androgens and fat mass in men. J Clin Endocrinol Metab, 92: 4878-4882. All publications 2007
1178. Takase, Y., Luu-The, V., Poisson-Paré, D., Labrie, F., Pelletier, G. (2007) Expression of sulfotransferase 1E1 in human prostate as studied by in situ hybridization and immunocytochemistry. Prostate, 67: 405-409. All publications 2007
1177. Tenta, R., Katopodis, H., Chatzïioannou, A., Pilalis, E., Calvo, E., Luu-The, V., Labrie, F., Kolisis, F., Koutsilieris, M. (2007) Microarray analysis of survival pathways in human PC-3 prostate cancer cells. Cancer Genomics Proteomics, 4: 309-18. All publications 2007
1176. Vandenput, L., Labrie, F., Mellström, D., Swanson, C., Knutsson, T., Peeker, R., Ljunggren, O., Orwoll, E., Eriksson, A.L., Johnell, O., Damber, J.E., Ohlsson, C. (2007) Serum levels of specific glucuronidated androgen metabolites predict BMD and prostate volume in elderly men. J. of Bone and Mineral Research: The Official Journal of the American Soc. for Bone and Mineral Research, 22: 220-7. All publications 2007
1175. Labrie, F. (2007) Drug insight: breast cancer prevention and tissue-targeted hormone replacement therapy. Nat Clin Pract Endocrinol Metab, 3: 584-93. All publications 2007
1174. Luu-The, V., Ferraris, C., Duche, D., Bélanger, P., Leclaire, J., Labrie, F. (2007) Steroid metabolism and profile of steroidogenic gene expression in EpiskinTM: High similarity with human epidermis. J Steroid Biochem Mol Biol 107: 30-36. All publications 2007
1173. Liu, H., Zheng, S.F., Bellemare, V., Pelletier, G., Labrie, F., Luu-The, V. (2007) Expression and localization of estrogenic type 12 17?-hydroxysteroid dehydrogenase in the cynomolgus monkey. BMC Biochem, 8: 2. All publications 2007
1172. Labrie, F., Bélanger, A., Bélanger, P., Bérubé, R., Martel, C., Cusan, L., Gomez, J., Candas, B., Chaussade, V., Castiel, I., Deloche, C., Leclaire, J. (2007) Metabolism of DHEA in postmenopausal women following percutaneous administration., 103: 178-88. All publications 2007
1171. Labrie, F., Bélanger, A., Labrie, C., Candas, B., Cusan, L., Gomez, J.L. (2007) Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women. J Steroid Biochem Mol Biol, 107: 57-69. All publications 2007
1170. Liu, H., Bellemare, V., Labrie, F., Luu-The, V. (2007) Molecular characterization of the cynomolgus monkey Macaca fascicularis steroidogenic enzymes belonging to the aldo-keto reductase family. J Steroid Biochem Mol Biol, 104: 75-80. All publications 2007
1169. Swanson, C., Lorentzon, M., Vandenput, L., Labrie, F., Rane, A., Jakobsson, J., Chouinard, S., Bélanger, A., Ohlsson, C. (2007) Sex steroid levels and cortical bone size in young men are associated with a uridine diphosphate glucuronosyltransferase 2B7 polymorphism (H268Y). J Clin Endocrinol Metab, 92: 3697-704. All publications 2007
1168. Vandenput, L., Mellström, D., Lorentzon, M., Swanson, C., Karlsson, M.K., Brandberg, J., Lönn, L., Orwoll, E., Smith, U., Labrie, F., Ljunggren, O., Tivesten, A., Ohlsson, C. (2007) Androgens and glucuronidated androgen metabolites are associated with metabolic risk factors in men. J Clin Endocrinol Metab, 92: 4130-7. All publications 2007
1167. Sancéau, J.-Y., Larouche, D., Caron, B., Bélanger, P., Coquet, A., Bélanger, A., Labrie, F., Gauthier, S. (2007) Synthesis and deuterium labelling of the pure selective estrogen receptor modulator (SERM) acolbifene glucuronides. J. of Label Compd and Radiopharm, 50: 197-206. All publications 2007
1166. Faucher, F., Cantin, L., Pereira de Jésus-Tran, K., Lemieux, M., Luu-The, V., Labrie, F., Breton, R. (2007) Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J. Mol. Biol., 369: 525-540. All publications 2007
1165. Ivanga, M., Labrie, Y., Calvo, E., Belleau, P., Martel, C., Luu-The, V., Morissette, J., Labrie, F., Durocher, F. (2007) Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway key components in the mouse uterus. Physiol Genomics, 29: 13-23. All publications 2007
1164. Labrie, F., Bélanger, A., Luu-The, V. (2007) Biosynthèse et sécrétion des hormones stéroïdiennes, in: Chanson, P., ed. Traité d'Endocrinologie, Paris: Flammarion Médecine-Sciences, pp 13-19. All publications 2007
1163. Pelletier, G., Luu-The, V., Li, S., Bujold, G., Labrie, F. (2007) Localization and glucocorticoid regulation of 11 ?-hydroxysteroid dehydrogenase type 1 mRNA in the male mouse forebrain. Neuroscience, 145: 110-115. All publications 2007
1162. Qiu, W., Zhou, M., Mazumdar, M., Azzi, A., Ghanmi, D., Luu-The, V., Labrie, F., Lin, S.-X. (2007) Structure-based inhibitor design for an enzymeTHAT binds different steroids: a potent inhibitor for human type 5 17?-hydroxysteroid dehydrogenase. J Steroid Biochem Mol Biol, 282: 8368-79. All publications 2007
1161. Pelletier, G., Li, S., Luu-The, V., Labrie, F. (2007) Oestrogenic regulation of pro-opiomelanocortin, neuropeptide Y and corticotrophin-releasing hormone mRNAs in mouse hypothalamus. J Neuroendocrinol, 19: 426-31. All publications 2007
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