Fernand Labrie

Publications

Page 2 of 25, showing 50 records out of 1234 total, starting on record 51, ending on 100

Publication Category Year
1184. Ciobanu, L.C., Boivin, R.P., Luu-The, V., Labrie, F., Poirier, D. (1999) Potent inhibition of steroid sulfatase activity by 3-Ο-sulfamate-17α-benzyl (or 4'-tert-butylbenzyl)-estra-1,3,5(10)-trienes: combination of two substituents at positions C3 and C17α of estradiol. J. Med. Chem., 42: 2280-2286. All publications 1999
1183. Ciobanu, L.C., Luu-The, V., Martel, C., Labrie, F., Poirier, D. (2003) Inhibition of estrone sulfate-induced uterine growth by potent nonestrogenic steroidal inhibitors of steroid sulfatase. Cancer Res., 63: 6442-6446. All publications 2003
1182. Compère, V., Ouellet, J., Luu-The, V., Dureuil, B., Tonon, M.C., Vaudry, H., Labrie, F., Pelletier, G. (2006) Role of androgens and glucocorticoids in the regulation of diazepam-binding inhibitor mRNA levels in male mouse hypothalamus. Brain Res. 1119: 50-7. All publications 2006
1181. Couët, J., Martel, C., Labrie, Y., Luo, S., Simard, J., Labrie, F. (1994) Opposite effects of prolactin and corticosterone on the expression and activity of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase in rat skin. J. Invest. Dermatol., 103: 60-64. All publications 1994
1180. Couch, F.J., Rommens, J.M., Neuhausen, S.L., Bélanger, C., Dumont, M., Abel, K., Bell, R., Berry, S., Bogden, R., Cannon-Albright, L., Farid, L., Frye, C., Hattier, T., Janecki, T., Jiang, P., Kehrer, R., Leblanc, J.F., McArthur-Morrison, J., McSweeney, D., Miki, Y., Peng, Y., Samson, C., Schroeder, M., Snyder, S.C., Stringfellow, M., Stroup, C., Swedlund, B., Swensen, J., Teng, D., Thakur, S., Tran, T., Tranchant, M., Welver-Feldhaus, J., Wong, A.K.C., Sjoziua, J., Labrie, F., Skolnick, M.H., Goldgar, D.E., Kamb, A., Weber, B.L., Tavtigian, S.V., Simard, J. (1996) Generation of an integrated transcription map of the BRCA2 region on chromosome 13q12-q13. Genomics, 36: 86-99. All publications 1996
1179. Couillard, S., Gutman, M., Labrie, C., Bélanger, A., Candas, B., Labrie, F. (1998) Comparison of the effects of the antiestrogens EM-800 and Tamoxifen on the growth of human breast ZR-75-1 cancer xenografts in nude mice. Cancer Res., 58: 60-64. All publications 1998
1178. Couillard, S., Gutman, M., Labrie, F., Candas, B., Labrie, C. (1999) Effect of the combined treatment with the pure antiestrogen EM-800 and radiotherapy on the growth of human ZR-75-1 breast cancer xenografts in nude mice. Cancer Res., 59: 4857-4863. All publications 1999
1177. Couillard, S., Labrie, C., Bélanger, A., Candas, B., Pouliot, F., Labrie, F. (1998) Effect of dehydroepiandrosterone and the antiestrogen EM-800 on growth of human ZR-75-1 breast cancer xenografts. J. Natl. Cancer Inst., 90: 772-778. All publications 1998
1176. Couillard, S., Labrie, C., Gauthier, S., Mérand, Y., Singh, S.M., Candas, B., Labrie, F. (2000) Long-term inhibitory effect of the orally active and pure antiestrogen EM-800 on the growth of human breast cancer xenografts in nude mice. Int. J. Cancer, 85: 424-429. All publications 2000
1175. Couture, J.-F., Cantin, L., Legrand, P., Luu-The, V., Labrie, F., Breton, R. (2002) Expression, crystallization and preliminary X-ray analysis of human and rabbit 20alpha-hydroxysteroid dehydrogenases in complex with NADP(H) and various steroid substrates. Acta Cryst. D. Biol. Crystallogr., D58: 135-139. All publications 2002
1174. Couture, J.-F., Legrand, P., Cantin, L., Luu-The, V., Labrie, F., Breton, R, (2003) Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids. J.Mol. Biol., 331: 593-604. All publications 2003
1173. Couture, J.-F., Legrand, P., Cantin, L., Luu-The, V., Labrie, F., Breton, R. (2004) Loop relaxation, a mechanism which explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. J.Mol. Biol., 339: 89-102. All publications 2004
1172. Couture, J.-F., Pereira de Jésus-Trans, K., Roy, A.-M., Cantin, L., Côté, P.-L., Legrand, P., Luu-The, V., Labrie, F., Breton, R. (2005) Comparison of crystal structures of human type 3 3alpha-hydroxysteroid dehydrogenase reveals an "induced-fit" mechanism and a conserved basic motif involved in the binding of androgen. Protein Science, 14: 1485-1497. All publications 2005
1171. Couture, P., Thériault, C., Simard, J., Labrie, F. (1993) Androgen receptor-mediated stimulation of 17β-hydroxysteroid dehydrogenase activity by dihydrotestosterone and medroxyprogesterone acetate in ZR-75-1 human breast cancer cells. Endocrinology, 132: 179-185. All publications 1993
1170. Crawford, E.D., Miller, G., Labrie, F., Hirano, D., Batuello, J., Globe, M. (2001) Prostate cancer pathology, screening and epidemiology. Reviews in Urology, 3: S2-S10. All publications 2001
1169. Cusan, L., Dupont, A., Cossette, M., Labrie, F. (1993) Flutamide in the treatment of female androgenic alopecia. Can. J. Dermatol., 5: 421-427. All publications 1993
1168. Cusan, L., Dupont, A., Gomez, J.L., Tremblay, R.R., Labrie, F. (1994) Comparison of Flutamide and spironolactone in the treatment of hirsutism: a randomized controlled trial. Fertil. Steril., 61: 281-287. All publications 1994
1167. Cusan, L., Gomez, J.L., Diamond, P., Candas, B., Labrie, F. (1996) Combined androgen blockade with GnRH analogues and Flutamide at all stages of prostate cancer (Chapter 15), in: Filicori, M. et Flamigni, C., eds: Treatment with GnRH Analogs: Controversies and Prospectives, New-York, The Parthenon Publishing Group, pp 125-137. All publications 1996
1166. Cusan, L., Gomez, J.L., Dupont, A., Diamond, P., Lemay, M., Moore, S., Labrie, F. (1994) Metastatic prostate cancer pulmonary nodules: beneficial effects of combination therapy and subsequent withdrawal of flutamide. Prostate, 24: 257-261. All publications 1994
1165. Dalla Valle, L., Couet, J., Labrie, Y., Simard, J., Belvedere, P., Simontacchi, C., Labrie, F., Colombo, L. (1995) Occurrence of cytochrome 450c17 mRNA and dehydroepiandrosterone biosynthesis in the rat gastrointestinal tract. Mol. Cell. Endocrinol., 111: 83-92. All publications 1995
1164. de Launoit, Y., Simard, J., Zhao, H.F., Couture, P., Labrie, F. (1993) Structure-function relationships of multiple rat members of the 3β-hydroxysteroid dehydrogenase family (Chapter 14), in: Leung, P.C.K. et Hsueh, A.J.W., eds: Molecular Basis of Reproductive Endocrinology, New York, Springer-Verlag, pp 201-209. All publications 1993
1163. Diamond, P., Cusan, L., Gomez, J.L., Bélanger, A., Labrie, F. (1996) Metabolic effects of 12-month percutaneous DHEA replacement therapy in postmenopausal women. J. Endocrinol., 150 Suppl.: S43-S50. All publications 1996
1162. Dimitrakakis, C., Zhou, J., Wang, J., Belanger, A., Labrie, F., Cheng, C., Powell, D., Bondy, C. (2003) A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause, 10: 292-298. All publications 2003
1161. Dinel, S., Bolduc, C., Belleau, P., Boivin, A., Yoshioka, M., Calvo, E., Piedboeuf, B., Snyder, E.E., Labrie, F., St-Amand, J. (2005) Reproducibility bioinformatic analaysis and power of SAGE method to evaluate changes in transcriptome. Nucleic Acids Res., 33:e26: 1-8. All publications 2005
1160. Dionne, P., Singh, S.M., Labrie, F. (1994) 1H and 13C nuclear magnetic resonance assignments and stereochemistry of N-n-butyl-n-methyl-11-(16'?-chloro-3',17'? (and 17?)-dihydroxy-estra-1',4',5'(10')-trien-7?-yl) undecanamide. Steroids, 59: 493-497. All publications 1994
1159. Donet, E., Bayo, P., Calvo, E., Labrie, F., Pérez, P. (2008) Identification of novel glucocorticoid receptor-regulated genes involved in epidermal homeostasis and hair follicle differentiation. J Steroid Biochem Mol Biol, 108: 8-16. All publications 2008
1158. Dosa, L., Sandler, H.M., Labrie, F., Kane, C. (2005) Prostate cancer management shows major shift in PSA era. Urol Times, 33: 9. All publications 2005
1157. Doualla-Bell, F., Bonneau, M.J., Labrie, F., Fortier, M.A. (1995) Differential effects of a steroidal antiestrogen, EM-139, on prostaglandin and cAMP production in the circular and longitudinal layers of bovine myometrium. Biol. Reprod., 52: 1358-1363. All publications 1995
1156. Doualla-Bell, F., Lye, S.J., Labrie, F., Fortier, M.A. (1995) Differential expression and regulation of connexin-43 and cell-cell coupling in myocytes from the circular and longitudinal layers of bovine myometrium. Endocrinology, 136: 5322-5328. All publications 1995
1155. Dufort, I., Labrie, F., Luu-The, V. (2001) Human types 1 and 3 3?-hydroxysteroid dehydrogenases: differential lability and tissue distribution. J. Clin. Endocrinol. Metab., 86: 841-846. All publications 2001
1154. Dufort, I., Soucy, P., Labrie, F., Luu-The, V. (1996) Molecular cloning of human type 3 3alpha-hydroxysteroid dehydrogenase that differs from 20alpha-hydroxysteroid dehydrogenase by seven amino acids. Biochem. Biophys. Res. Commun., 228: 474-479. All publications 1996
1153. Dufort, I., Tremblay, Y., Bélanger, A., Labrie, F., Luu-The, V. (1996) Isolation and characterization of a stereospecific 3β-hydroxysteroid sulfotransferase (pregnenolone sulfotransferase) cDNA. DNA Cell Biol., 15: 481-487. All publications 1996
1152. Dumont, M., Frank, D., Moisan, A.-M., Tranchant, M., Soucy, P., Breton, R., Labrie, F., Tavtigian, S.V., Simard, J. (2004) Structure of primate and rodent orthologs of the prostate cancer susceptibility gene ELAC2. Biochimica et Biophysica Acta, 1679: 230-247. All publications 2004
1151. Dupont, A., Cusan, L., Gomez, J.L., Koutsilieris, M., Suburu, R., Emond, J., Labrie, F. (1993) Combination therapy with Flutamide and the LHRH agonist [D-Trp6-des-Gly-NH2]LHRH ethylamide in stage C prostatic carcinoma. Br. J. Urol., 72: 629-634. All publications 1993
1150. Dupont, A., Gomez, J.L., Cusan, L., Koutsilieris, M., Labrie, F. (1993) Response to Flutamide withdrawal in advanced prostate cancer in progression under combination therapy. J. Urol., 150: 908-913. All publications 1993
1149. Dupont, E., Labrie, F., Luu-The, V., Pelletier, G. (1993) Ontogeny of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) in rat testis as studied by immunocytochemistry. Anat. Embryol. (Berl.), 187: 583-589. All publications 1993
1148. Dupont, E., Simard, J., Luu-The, V., Labrie, F., Pelletier, G. (1994) Localization of 3β-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization. Mol. Cell. Neurosci., 5: 119-123. All publications 1994
1147. Durocher, F., Morissette, J., Labrie, Y., Labrie, F., Simard, J. (1995) Mapping of the HSD17?2 gene encoding type II 17β-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q 24.1-q24.2. Genomics, 25: 724-726. All publications 1995
1146. Durocher, F., Shattuck-Eidens, D., McClure, M., Labrie, F., Skolnick, M.H., Goldgar, D.E., Simard, J. (1996) Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations. Hum. Mol. Genet., 5: 835-842. All publications 1996
1145. Durocher, F., Simard, J., Ouellette, J., Richard, V., Labrie, F., Pelletier, G. (1997) Localization of the BRCA1 gene expression in adult cynomolgus monkey tissues. J. Histochem. Cytochem., 45: 1173-1188. All publications 1997
1144. El-Alfy, M., Luu-The, V., Huang, X.F., Berger, L., Labrie, F., Pelletier, G. (1999) Localization of type 5 17β-hydroxysteroid dehydrogenase, 3 β-hydroxysteroid dehydrogenase and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. Endocrinology, 140: 1481-1491. All publications 1999
1143. El-Alfy, M., Pelletier, G. Hermo, L.S., Labrie, F. (2000) Unique features of the basal cells of human prostate epithelium. Microsc. Res. Tech., 51: 436-446. All publications 2000
1142. Eriksson, A.L., Lorentzon, M., Mellstrom, D., Vandenput, L., Swanson, C., andersson, N., Hammond, G.L., Jakobsson, J., Rane, A., Orwoll, E.S., Ljunggren, O., Johnell, O., Labrie, F., Windahl, S.H., Ohlsson, C. (2006) SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. J Clin Endocrinol Metab, 91: 5029-37. All publications 2006
1141. Eriksson, A.L., Lorentzon, M., Vandenput, L., Labrie, F., Lindersson, M., Syvänen, A.C., Orwoll, E.S., Cummings, S.R., Zmuda, J.M., Ljunggren, O., Karlsson, M.K., Mellström, D., Ohlsson, C. (2009) Genetic Variations in Sex Steroid-Related Genes as Predictors of Serum Estrogen Levels in Men. J. Clin Endocrinol, Metab, 94: 1033-1041. All publications 2009
1140. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) Crystal structures of human Δ4-3-ketosteroid 5β-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Biochemistry, 47: 13537-13546. All publications 2008
1139. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) The crystal structure of human Δ4-3-ketosteroid 5β-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry, 47: 8261-8270. All publications 2008
1138. Faucher, F., Cantin, L., Pereira de Jésus-Tran, K., Lemieux, M., Luu-The, V., Labrie, F., Breton, R. (2007) Mouse 17α-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J. Mol. Biol., 369: 525-540. All publications 2007
1137. Faucher, F., Pereira de Jésus-Trans, K., Cantin, L., Luu-The, V., Labrie, F., Breton, R. (2006) Crystal structures of mouse 17β-hydroxysteroid dehydrogenase (Apoenzyme and enzyme-NADP(H) binary complex): Identification of molecular determinants responsible for the unique 17β-reductive activity of this enzyme. J.Mol. Biol., 364: 747-763. All publications 2006
1136. Forsblad d'Elia, H., Carlsten, H., Labrie, F., Konttinen, Y., Ohlsson, C. (2009) Low serum levels of sex-steroids are associated with disease characteristics in primary Sjögren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations, J Clin Endocrinol Metab, 94: 2044-51. All publications 2009
1135. Gauthier, S., Caron, B., Cloutier, J., Dory, Y.L., Favre, A., Larouche, D., Mailhot, J., Ouellet, C., Schwerdtfeger, A., Leblanc, G., Martel, C., Simard, J., Mérand, Y., Bélanger, A., Labrie, C., Labrie, F. (1997) (S)-(+)-[4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl) ethoxy]phenyl]-2H-1-benzopyran-3-yl]phenyl]-2,2-dimethylpropanoate (EM-800): a highly potent, specific and orally active non-steroidal antiestrogen. J. Med. Chem., 40: 2117-2122. All publications 1997
<< previous | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 next >>

Biography  |  Publications  |  Scientific Conferences  |  Selected Slide Presentations  |  Awards