Fernand Labrie

Publications

Page 4 of 26, showing 50 records out of 1263 total, starting on record 151, ending on 200

Publication Category Year
995. Dupont, E., Labrie, F., Luu-The, V., Pelletier, G. (1991) Localization of 17beta-hydroxysteroid dehydrogenase throughout gestation in the human placenta. J. Histochem. Cytochem., 39: 1403-1407. All publications 1991
975. Dupont, E., Labrie, F., Luu-The, V., Pelletier, G. (1992) Immunocytochemical localization of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) in human ovary. J. Clin. Endocrinol. Metab., 74: 994-998. All publications 1992
956. Dupont, E., Labrie, F., Luu-The, V., Pelletier, G. (1993) Ontogeny of 3β-hydroxysteroid dehydrogenase/Δ5-Δ4 isomerase (3β-HSD) in rat testis as studied by immunocytochemistry. Anat. Embryol. (Berl.), 187: 583-589. All publications 1993
1027. Dupont, E., Luu-The, V., Labrie, F., Pelletier, G. (1990) Light microscopic immunocytochemical localization of 3beta-hydroxy-5-ene-steroid dehydrogenase/delta5-delta4 isomerase in the gonads and adrenal glands of the guinea pig. Endocrinology. 126: 2906-2909. All publications 1990
1028. Dupont, E., Luu-The, V., Labrie, F., Pelletier, G. (1990) Ontogeny of 3beta-hydroxysteroid dehydrogenase/delta5-delta4 isomerase (3beta-HSD) in human adrenal gland performed by immunocytochemistry. Mol. Cell. Endocrinol. 74: R7-R10. All publications 1990
996. Dupont, E., Luu-The, V., Labrie, F., Pelletier, G. (1991) Ontogeny of 3beta-hydroxysteroid dehydrogenase/ Delta5-Delta4 isomerase (3beta-HSD) in human testis as studied by immunocytochemistry. J. Androl., 12: 161-164. All publications 1991
997. Dupont, E., Rhéaume, E., Simard, J., Luu-The, V., Labrie, F., Pelletier, G. (1991) Ontogenesis of 3beta-hydroxysteroid dehydrogenase/Delta5-Delta4 isomerase in the rat adrenal as revealed by immunocytochemistry and in situ hybridization. Endocrinology, 129: 2687-2692. All publications 1991
931. Dupont, E., Simard, J., Luu-The, V., Labrie, F., Pelletier, G. (1994) Localization of 3β-hydroxysteroid dehydrogenase in rat brain as studied by in situ hybridization. Mol. Cell. Neurosci., 5: 119-123. All publications 1994
1029. Dupont, E., Zhao, H.F., Rhéaume, E., Simard, J., Luu-The, V., Labrie, F., Pelletier, G. (1990) Localization of 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase in rat gonads and adrenal glands by immunocytochemistry and in situ hybridization. Endocrinology. 127: 1394-1403. All publications 1990
901. Durocher, F., Morissette, J., Labrie, Y., Labrie, F., Simard, J. (1995) Mapping of the HSD17B2 gene encoding type II 17beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q 24.1-q24.2. Genomics, 25: 724-726. All publications 1995
453. Durocher, F., Shattuck-Eidens, D., McClure, M., Labrie, F., Skolnick, M.H., Goldgar, D.E., Simard, J. (1996) Comparison of BRCA1 polymorphisms, rare sequence variants and/or missense mutations in unaffected and breast/ovarian cancer populations. Hum. Mol. Genet., 5: 835-842. All publications 1996
362. Durocher, F., Simard, J., Ouellette, J., Richard, V., Labrie, F., Pelletier, G. (1997) Localization of the BRCA1 gene expression in adult cynomolgus monkey tissues. J. Histochem. Cytochem., 45: 1173-1188. All publications 1997
806. El-Alfy, M., Luu-The, V., Huang, X.F., Berger, L., Labrie, F., Pelletier, G. (1999) Localization of type 5 17beta-hydroxysteroid dehydrogenase, 3beta-hydroxysteroid dehydrogenase and androgen receptor in the human prostate by in situ hybridization and immunocytochemistry. Endocrinology, 140: 1481-1491. All publications 1999
45. El-Alfy, M., Pelletier, G. Hermo, L.S., Labrie, F. (2000) Unique features of the basal cells of human prostate epithelium. Microsc. Res. Tech., 51: 436-446. All publications 2000
180. Emond, J., Dupont, A., Cusan, L., Bergeron, N., Manhès, G., Labrie, F. (1989) Combination therapy with Flutamide and castration (LHRH agonist or orchiectomy) as an alternative to transurethral resection of the prostate for urinary retention in prostate cancer, in: Labrie, F., Lee, F. et Dupont, A., eds: Early Stage Prostate Cancer: Diagnosis and Choice of Therapy, North Holland, Elsevier, pp 103-108. All publications 1989
571. Eriksson, A.L., Lorentzon, M., Mellstrom, D., Vandenput, L., Swanson, C., andersson, N., Hammond, G.L., Jakobsson, J., Rane, A., Orwoll, E.S., Ljunggren, O., Johnell, O., Labrie, F., Windahl, S.H., Ohlsson, C. (2006) SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density. J Clin Endocrinol Metab, 91: 5029-37. All publications 2006
4696. Eriksson, A.L., Lorentzon, M., Vandenput, L., Labrie, F., Lindersson, M., Syvänen, A.C., Orwoll, E.S., Cummings, S.R., Zmuda, J.M., Ljunggren, O., Karlsson, M.K., Mellström, D., Ohlsson, C. (2009) Genetic Variations in Sex Steroid-Related Genes as Predictors of Serum Estrogen Levels in Men. J. Clin Endocrinol, Metab, 94: 1033-1041. All publications 2009
4697. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) Crystal structures of human Delta4-3-ketosteroid 5beta-reductase (AKR1D1) reveal the presence of an alternative binding site responsible for substrate inhibition. Biochemistry, 47: 13537-13546. All publications 2008
4685. Faucher, F., Cantin, L., Luu-The, V., Labrie, F., Breton, F. (2008) The crystal structure of human delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry, 47: 8261-8270. All publications 2008
729. Faucher, F., Cantin, L., Pereira de Jésus-Tran, K., Lemieux, M., Luu-The, V., Labrie, F., Breton, R. (2007) Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate binding. J. Mol. Biol., 369: 525-540. All publications 2007
572. Faucher, F., Pereira de Jésus-Trans, K., Cantin, L., Luu-The, V., Labrie, F., Breton, R. (2006) Crystal structures of mouse 17beta-hydroxysteroid dehydrogenase (Apoenzyme and enzyme-NADP(H) binary complex): Identification of molecular determinants responsible for the unique 17beta-reductive activity of this enzyme. J.Mol. Biol., 364: 747-763. All publications 2006
4703. Forsblad d'Elia, H., Carlsten, H., Labrie, F., Konttinen, Y., Ohlsson, C. (2009) Low serum levels of sex-steroids are associated with disease characteristics in primary Sjögren's syndrome; supplementation with dehydroepiandrosterone restores the concentrations, J Clin Endocrinol Metab, 94: 2044-51. All publications 2009
438. Gauthier, S., Caron, B., Cloutier, J., Dory, Y.L., Favre, A., Larouche, D., Mailhot, J., Ouellet, C., Schwerdtfeger, A., Leblanc, G., Martel, C., Simard, J., Mérand, Y., Bélanger, A., Labrie, C., Labrie, F. (1997) (S)-(+)-[4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl) ethoxy]phenyl]-2H-1-benzopyran-3-yl]phenyl]-2,2-dimethylpropanoate (EM-800): a highly potent, specific and orally active non-steroidal antiestrogen. J. Med. Chem., 40: 2117-2122. All publications 1997
663. Gauthier, S., Cloutier, J., Dory, Y.L., Favre, A., Mailhot, J., Ouellet, C., Schwerdteeger, A., Mérand, Y., Martel, C., Simard, J., Labrie, F. (2005) Synthesis and structure-activity relationships of analogs of EM-652 (acobifene), a pure selective estrogen receptor modulator. Study of mitrogen substitution. J of Enzyme Inhibition and Medicinal Chemistry, 20: 165-177. All publications 2005
902. Ghosh, D., Pletnev, V.Z., Zhu, D.-W., Wawrzak, Z., Duax, W.L., Pangborn, W., Labrie, F., Lin, S.-X. (1995) Structure of human estrogenic 17beta-hydroxysteroid dehydrogenase at 2.20 a resolution. Structure, 3: 503-513. All publications 1995
3828. Ghosh, D., Wawrzak, Z., Pletnev, V., Erman, M., Duax, W.L., Pangborn, W., Zhu, D.W., Labrie, F., Lin, S.X. (1995) Molecular mechanism of inhibition of steroid dehydrogenases by licorice-derived steroid analogs in modulation of steroid receptor function. Ann. N. Y. Acad. Sci., 761: 341-343. All publications 1995
3600. Gingras, S., Turgeon, C., Brochu, N., Labrie, F., Simard, J. (2003) Characterization and modulation of sex steroid metabolizing activity in normal human keratinocytes in primary culture and hacat cells. J. Steroid Biochem Mol Biol, 87: 167-79. All publications 2003
37. Gomella, L.G., Labrie, F., Gamito, E.J., Brawer, M.K. (2001) Prostate cancer: risk assessment and diagnostic approaches. Reviews in Urology, 3: S31-S38. All publications 2001
147. Gomez, J.L., Dupont, A., Cusan, L., Tremblay, M., Suburu, E.R., Lemay, M., Labrie, F. (1992) Incidence of liver toxicity associated with the use of Flutamide in prostate cancer patients. Am. J. Med., 92: 465-470. All publications 1992
148. Gomez, J.L., Dupont, A., Cusan, L., Tremblay, M., Tremblay, M., Labrie, F. (1992) Simultaneous liver and lung toxicity related to the non-steroidal antiandrogen Nilutamide (Anandron): a case report. Am. J. Med., 92: 563-566. All publications 1992
903. Guérin, S.L., Leclerc, S., Verreault, H., Labrie, F., Luu-The, V. (1995) Overlapping cis-acting elements located in the first intron of the gene for type I 3beta-hydroxysteroid dehydrogenase modulate its transcriptional activity. Mol. Endocrinol., 9: 1583-1597. All publications 1995
388. Gutman, M., Couillard, C., Labrie, F., Candas, B., Labrie, C. (2003) Effect of treatment sequence with radiotherapy and the antiestrogen EM-800 on the growth of ZR-75-1 Human mammary carcinoma in nude mice. Int J Cancer, 103: 268-276. All publications 2003
417. Gutman, M., Couillard, S., Labrie, F., Candas, B., Labrie, C. (1999) Effects of the antiestrogen EM-800 (SCH 57050) and cyclophosphamide alone and in combination on growth of human ZR-75-1 breast cancer xenografts in nude mice. Cancer Res., 59: 5176-5180. All publications 1999
393. Gutman, M., Couillard, S., Roy, J., Labrie, F., Candas, B., Labrie, C. (2002) Comparison of the effects of EM-652 (SCH57068), tamoxifen, toremifene, droloxifene, idoxifene, GW-5638 and raloxifene on the growth of human ZR-75-1 breast tumors in nude mice. International Journal of Cancer, 99: 273-278. All publications 2002
3664. Gyomorey, S., Gupta, S., Lye, S.J., Gibb, W., Labrie, F., Challis, J.R.G. (2000) Temporal expression of prostaglandin H synthase type 2 (PGHS-2) and P450c17 in ovine placentomes with the natural onset of labour. Placenta, 21: 478-486. All publications 2000
4691. Han, B., Li, S., Song, D., Poisson-Paré, D., Liu, G., Luu-The, V., Ouellet, J., Li, S., Labrie, F., Pelletier, G. (2008) Expression of 17beta-hydroxysteroid dehydrogenase type 2 and type 5 in breast cancer and adjacent non-malignant tissue: a correlation to clinicopathological parameters. J Steroid Biochem Mol Biol, 112: 194-200 All publications 2008
3830. Han, X., Rossdale, P.D., Ousey, J., Holdstock, N., Allen, W.R., Silver, M., Fowden, A.L., McGladdery, A., Labrie, F., Bélanger, A., Ensor, C.M., Tai, H.H., Challis, J.R.G. (1995) Localization of 15-hydroxy prostaglandin dehydrogenase (PGDH) and steroidogenic enzymes in the equine placenta. Equine Vet. J., 27: 334-339. All publications 1995
418. Hida, N., Poulin, R., Veilleux, R., Labrie, F. (1999) Differential androgen sensitivity is associated with clonal heterogeneity in steroid metabolism, ornithine decarboxylase regulation and IL-1alpha action in mouse mammary tumor cells. J. Steroid Biochem. Mol. Biol., 71: 71-81. All publications 1999
730. Ivanga, M., Labrie, Y., Calvo, E., Belleau, P., Martel, C., Luu-The, V., Morissette, J., Labrie, F., Durocher, F. (2007) Temporal analysis of E2 transcriptional induction of PTP and MKP and downregulation of IGF-I pathway key components in the mouse uterus. Physiol Genomics, 29: 13-23. All publications 2007
389. Jensen, J., Kitlen, J., Briand, P., Labrie, F., Lykkesfeldt, A.E. (2003) Effect of antiestrogens and aromatase inhibitor on basal growth of the human breast cancer cell line MCF-7 in serum-free medium. J. Steroid Biochem Mol Biol, 84: 469-78. All publications 2003
957. Juneau, C., Dupont, E., Luu-The, V., Labrie, F., Pelletier, G. (1993) Ontogenesis of 3β-hydroxysteroid dehydrogenase Δ5-Δ4 isomerase in the rat ovary as studied by immunocytochemistry and in situ hybridization. Biol. Reprod., 48: 226-234. All publications 1993
58. Kelloff, G.J., Lieberman, R., Brawer, M.K., Crawford, E.D., Labrie, F., Miller, G.J. (1999) Strategies for chemoprevention of prostate cancer. Prostate Cancer and Prostatic Diseases, 2: 27-33. All publications 1999
123. Koutsilieris, M., Dupont, A., Gomez, J.L., Cusan, L., Suburu, R., Diamond, P., Labrie, F. (1994) Stratification of stage D2 prostate cancer patients by a disease aggressiveness score and its use in evaluating disease response and outcome to combination hormonal therapy (GnRH-A plus Flutamide). Anticancer Res., 14: 627-634. All publications 1994
481. Lévesque, C., Mérand, Y., Dufour, J.M., Labrie, C., Labrie, F. (1991) Synthesis and biological activity of new halo-steroidal antiestrogens. J. Med. Chem., 34: 1624-1630. All publications 1991
4707. Lévesque, M.H., El-Alfy, M., Cusan, L., Labrie, F. (2009) Androgen receptor as a potential sign of prostate cancer metastasis, The Prostate, 69: 1704-1711. All publications 2009
96. Labrie, C., Flamand, M., Bélanger, A., Labrie, F. (1996) High bioavailability of DHEA administered percutaneously in the rat. J. Endocrinol., 150: S107-S118. All publications 1996
408. Labrie, C., Labrie, F., Bélanger, A., Simard, J., Luo, S., Martel, C. (2000) EM-652 (SCH 57068), a third generation SERM (selective estrogen receptor modulator), acting as pure antiestrogen in the mammary gland and endometrium, in: Coutinho, E.M. et Spinola, P., eds: Current Knowledge in Reproductive Medicine. Proceedings of the 10th World Congress on Human Reproduction, Salvador, Brazil, 4-8th May 1999, Elsevier Science B.V., pp 381-397. All publications 2000
998. Labrie, C., Martel, C., Couet, J., Trudel, C., Luu-The, V., Labrie, F. (1991) Pituitary hormone regulation of ovarian 3beta-HSD gene expression and activity in the rat (Chapter 27), in: Gibori, G., ed. Signaling Mechanisms and Gene Expression in the Ovary (Serono Symposia), New York, Springer-Verlag, pp 268-273. All publications 1991
473. Labrie, C., Martel, C., Dufour, J.M., Lévesque, C., Mérand, Y., Labrie, F. (1992) Novel compounds inhibit estrogen formation and action. Cancer Res., 52: 610-615. All publications 1992
167. Labrie, C., Simard, J., Poulin, M., Bélanger, A., Pelletier, G., Labrie, F. (1990) Influence of the duration of androgen deprivation on the sensitivity of the rat ventral prostate to dehydroepiandrosterone and androstenedione. In: Bradlow, H., Castagnetta, L., d'Aquino, S. et Labrie, F. eds. Steroid Formation, Degradation and Action in Peripheral Tissues, Normal and Neoplastic Tissues. Ann. New York Acad. Sci. pp 392-394. All publications 1990
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